SUNDAY, OCTOBER 26TH

VIRTUAL SESSIONS ARE NOT LIVE STREAMED. THEY WILL BE RECORDED AND PUBLISHED LATER FOR VIEWING.

7:30am - 5:00pm

Registration Open

8:00am - 9:50am

PLENARY SESSION 1 - Biology of Melanocytes to Melanoma

8:00am - 8:20am

How do melanoma cells communicate with their neighbors

Richard White

8:20am - 8:35am

Spatial gene expression and microenvironmental changes in the transition of nevus to melanoma

Inger Kreuger

8:35am - 8:55am

The roots of hair graying and melanoma

Emi Nishimura

8:55am - 9:10am

Parkinsons Disease and Melanoma: how they are connected and clues for melanoma pathogenesis

David Fisher

9:10am - 9:30am

Selected Abstract Talk - Plasticity Fuels Melanoma Dissemination and Organ Colonization

Marek Piprek

9:30am - 9:45am

Selected Abstract Talk - Uncovering Melanoma Cell State Dynamics In Vivo

Paco Lopez-Cuevas

9:45am - 9:51am

Poster Flash Talks

9:45am - 9:46am

CDH3-AS1 antisense RNA enhances P-cadherin translation and acts as a tumor suppressor in melanoma

Manon Chadourne

9:46am - 9:47am

BRAFV600E suppresses p53 in melanoma through direct protein–protein interaction

Kayla O’Toole

9:47am - 9:48am

CircPMS1 promotes melanoma metastasis through LIM domain RNA-binding proteins

Nicol Mecozzi

9:48am - 9:49am

Defining the persister cell state after melanoma therapy as a BMP-dependent intrinsic property

Maggie Chasse

9:49am - 9:50am

In vivo CRISPR knockout screen reveals Polr1a as a key driver and a potential therapeutic target for melanoma metastasis

Anna Fajardo

9:50am - 9:51am

Influence of Initial Primary Melanoma Stage on Survival Outcomes in Advanced Disease: Insights from a Spanish Real-World Registry

Maria González Cao

9:51am - 10:20am

Refreshment Break

10:20am - 11:50am

Poster Session 1

11:50am - 12:20pm

Lunch - Exhibit Hall & Posters

12:20pm - 1:20pm

PLENARY SESSION - Shifting the Lens: Equity and Innovation in Melanoma Science and Practice

12:20pm - 12:23pm

Intro

Patricia Possik & Marie Webster

12:23pm - 12:38pm

Reducing health care disparities: Care gaps in melanoma for patients of color

Leandra Alicia Barnes

12:38pm - 12:43pm

Translational tug-of-war: The struggle to serve both science and patients

Aslan Tasdogan

12:43pm - 1:15pm

Q&A/Discussion

1:15pm - 1:20pm

Wrap-Up

1:20pm - 2:05pm

Keynote Presentation 2

What can we learn from TIL therapy of melanoma?

John Haanen

2:05pm - 2:25pm

Refreshment Break

2:25pm - 4:15pm

PLENARY SESSION 2 - Intersection of Microbiome and Melanoma

2:25pm - 2:45pm

Improving various strategies to improve microbiome composition in melanoma patients

Bertrand Routy

2:45pm - 3:00pm

Oral microbiota as a modulator of melanoma brain metastasis development

Golnaz Morad

3:00pm - 3:20pm

Melanoma control by the gut microbiome

Ze'ev Ronai

3:20pm - 3:40pm

Mechanisms of regulation of anti-tumor immunity by the commensal microbiota

Tom Gajewski

RP1 monotherapy in solid organ transplant recipients with locally advanced cutaneous squamous cell carcinoma (ARTACUS)

3:40pm - 3:55pm

Michael Migden

3:55pm - 4:10pm

Neoadjuvant Intralesional Daromun Improves Outcomes in Pretreated, Relapsed Stage III Melanoma — Subgroup Analysis of the Phase 3 PIVOTAL Study

Caroline Robert

4:10pm - 4:15pm

Poster Flash Talks

4:10pm - 4:11pm

A function-to-transcriptome signature defines circulating tumor-reactive CD8 T cells in melanoma

Fang Zhao

4:11pm - 4:12pm

Schwann cell precursor–like and hybrid cell states drive melanoma metastasis and resistance to therapy

Kerri Marie

4:12pm - 4:13pm

Extended follow-up and response markers from conditioning-free TIL therapy with oncolytic adenovirus TILT-123 in the TUNINTIL phase 1 trial for advanced melanoma

Tatiana Kudling

4:13pm - 4:14pm

Efficacy of RP1 plus nivolumab in patients with advanced melanoma and primary resistance to prior anti–PD-1 therapy: A subgroup analysis from the IGNYTE trial

Caroline Robert

4:14pm - 4:15pm

First reported overall survival results from a phase 1/2 study of darovasertib (OptimUM-01) plus crizotinib as first-line treatment for metastatic uveal melanoma

Meredith McKean

4:15pm - 4:35pm

Refreshment Break

4:35pm - 6:25pm

PLENARY SESSION 3 - Melanoma Heterogeneity and Metabolism

Monitoring and targeting phenotype switching in melanoma

4:35pm - 4:55pm

Chris Marine

4:55pm - 5:10pm

The epigenetic regulator TRIM24 fosters tumor heterogeneity and controls melanoma cell dedifferentiation and resistance to treatment in melanoma

Simon Durand

5:10pm - 5:30pm

Melanosomes role in melanoma immunity

Carmit Levy

5:30pm - 5:45pm

Spatial determinants of tumor cell dedifferentiation and plasticity in primary cutaneous melanoma

Tuulia Vallius

5:45pm - 6:05pm

Metabolism: The new frontier in melanoma precision medicine

Alpaslan Tasdogan

6:05pm - 6:20pm

Cytidine diphosphate diacylglycerol synthase 2 is a synthetic lethal target in melanoma and mesenchymal-like cancers

Tim Arnoldus

6:20pm - 6:27pm

Poster Flash Talks

6:20pm - 6:21pm

Mechanisms of melanoma plasticity revealed through integration of dynamic modeling, single-cell trajectory inference and spatial profiling

Mohammad Fallahi-Sichani

6:21pm - 6:22pm

Nuclear architecture rewiring facilitates melanoma mesenchymal-like cells dissemination.

Pietro Berico

6:22pm - 6:23pm

Novel multiplex liquid biopsy assays to predict melanoma recurrence

Suzanah Boyd

6:23pm - 6:24pm

Lifileucel versus ipilimumab in metastatic or unresectable melanoma previously treated with immune checkpoint inhibitors (ICIs): A simulated treatment comparison (STC) approach

Murat Kurt

6:24pm - 6:25pm

Alternative GPCR signaling associated with CREB1 activation drives resistance to multiple targeted therapies in uveal melanoma

Eric Anderson

6:25pm - 6:26pm

Analysis of individualized and overlapping neoantigens in intismeran autogene (mRNA-4157/V940) from mRNA-4157-P201 (KEYNOTE-942) trial

Ryan Sullivan

6:26pm - 6:27pm

Reinvigoration and Exhaustion: Distinct Tumor Infiltrating Lymphocytes Responses to PD-1 Blockade in Melanoma

Monireh Kazemimanesh

6:30pm - 8:00pm

Poster Reception

8:00pm - 10:00pm

Trainee Night Out