VIRTUAL SESSIONS ARE NOT LIVE STREAMED. THEY WILL BE RECORDED AND PUBLISHED LATER FOR VIEWING.
7:30am - 5:00pm
Registration Open
8:00am - 9:45am
PLENARY SESSION 4 - Understanding and Optimizing the Immunotherapy Response (I)
8:00am - 8:20am
PD1 and memory a smoking gun in melanoma immunotherapy and toxicity
Niroshana Anandasabapathy
8:20am - 8:35am
Heterotypic CD8 T cell clusters isolated from clinical samples are biologically distinct and enriched for antitumor activity
Johanna Veldman
8:35pm - 8:55pm
Clinical translation of new approaches in TIL therapy for metastatic melanoma
Michelle Krogsgaard
8:55pm - 9:10am
Cytotoxic NK cells impede response to checkpoint immunotherapy in melanoma with an immune-excluded phenotype
Joanna Pozniak
9:10am - 9:30am
Improving mRNA vaccines in melanoma
Inge Svane
9:30am - 9:45am
A phase II trial on precision radiation of immune checkpoint therapy resistant melanoma metastases (PROMMEL)
Hildur Helgadottir
9:45am - 9:50am
Poster Flash Talks
9:45am - 9:46am
Targeting RAS to stimulate antitumor immunity in acral melanoma cells
Geethanjali Annamalai
9:46am - 9:47am
Insights into pan-RAF targeted therapy strategies for non-BRAF V600 genotypes and as salvage for BRAF/MEK inhibitor resistant melanoma
Aristophane Chay
9:47am - 9:48am
Investigating epithelial to mesenchymal transition heterogeneity in primary and metastatic uveal melanoma samples
Catherine Van Raamsdonk
9:48am - 9:49am
Regulatory T cells inhibit CD8+ TRM-like cells during the early stages of tumor immune escape
Jason Williams
9:49am - 9:50am
Characterizing the spatial transcriptomic landscape of metastatic melanoma patients treated with combination anti-LAG-3 + anti-PD-1 immunotherapies
Tuba Gide
9:50am - 10:10am
Refreshment Break
10:10am - 11:55am
PLENARY SESSION 5 - Melanoma Microenvironment
10:10am - 10:30am
Cancer’s cradle: How malignant cells and their niche trigger tumor initiation
Lukas Sommer
10:30am - 10:45am
Sensory neurons interact directly with melanoma malignant cells and pericytes via CGRP-RAMP1 signaling to promote melanoma metastatic outgrowth
Alexander Birbrair
10:45am - 11:05am
A complex TIME: How the aging tumor immune microenvironment impacts tumor progression and response to therapy
Ashi Weeraratna
11:05am - 11:20am
Cancer acquires therapy resistance by converting immune infiltration to exclusion through NK cell-macrophage interactions.
Andrew White
11:20am - 11:40am
Melanoma control by the gut microbiome
Ze'ev Ronai
11:40am - 11:55am
A Wnt-signaled subset of tumoral macrophages promotes melanoma progression
Alexandra Thornock
11:55am - 12:00pm
Poster Flash Talks
11:55am - 11:56pm
Downregulation of polycomb repressive complex 1 ubiquitin ligases following BAP1 loss drives uveal melanoma metastasis
Emma Hammes
11:56am - 11:57pm
Investigating the combined inhibition of RAF, MEK, and FAK in melanoma molecular subtypes
Jared Almazan
11:57am - 11:58pm
DNA methylation analysis of acral melanoma identifies an independently prognostic methylation signature and type I interferon downregulation in high-risk patients
Simon Roy
11:58am - 11:59pm
Immunotherapy resistance in melanoma: From tumour-resident archetypes to targetable gene networks
Andrea Di Pietro
11:59am - 12:00pm
YAP activity predicts tumor dormancy in uveal melanoma patients: Molecular and clinicopathological insights
Nikhil Kumar
12:00pm - 1:30pm
Lunch - Exhibit & Posters
1:30pm - 3:15pm
PLENARY SESSION 6 - Rare and Challenging Melanomas
1:30pm - 1:50pm
Defining therapeutic targets in rare melanomas using genome-wide and combinatorial CRISPR screening
David Adams
1:50pm - 2:05pm
A site-specific microenvironmental program in plantar skin confers heightened metastatic capacity to acral melanomas
Vito Rebecca
2:05pm - 2:25pm
TERT activation in acral and mucosal melanoma
James Wilmott
2:25pm - 2:40pm
Efficacy and safety of IMA203, a PRAME-directed T-cell receptor (TCR) T-cell therapy, in patients with previously treated advanced or metastatic uveal melanoma from a Ph 1 trial
Kelly Blacklock
2:40pm - 3:00pm
Spatial transcriptome of immunotherapy resistant melanoma
Boris Bastian
3:00pm - 3:15pm
Canine oronasal mucosal melanoma: a companion model for drug treatment
Sapna Patel
3:15pm - 3:35pm
Refreshment Break
3:35pm - 4:20pm
Keynote Presentation
Marisol Soengas
4:20pm - 6:00pm
PLENARY SESSION 7 - Understanding and Optimizing the Immunotherapy Response (II)
IMA203, a PRAME-directed T-cell receptor (TCR) T-cell therapy, demonstrated broad organ penetration in patients with heavily pretreated advanced or metastatic melanoma in a phase 1 trial
Martin Wermke
5:30pm - 5:45pm
Adjuvant nivolumab plus ipilimumab in high-risk uveal melanoma: Long-term survival outcomes from HCRN MEL17-309
Suthee Rapisuwon
5:45pm - 6:05pm
Understanding the effect of ICB by mapping the ecosystem of the anti-tumor immune response in melanoma