AGENDA
Wednesday, October 19th
7:30am - 5:00pm
Registration Open
Strathblane Foyer
8:00am-10:05am
PLENARY SESSION 4 - Tumor Heterogeneity, Plasticity and Persistence - Session Chair - Martin McMahon
Pentland Suite
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8:00am - 8:20am
A TCF4/BRD4-dependent regulatory network confers cross-resistance to targeted and immune checkpoint therapy in melanoma
Presented by: Florian Rambow
8:20am - 8:35am
Genetic regulation of dynamic stemness in melanocytes and melanoma
Presented by: Robert L. Judson- Torres
8:35am - 8:50am
ALDH1A3 regulates melanoma neural crest identity through histone H3 acetylation
Presented by: Yuting Lu
8:50am - 9:10am
Clonal subline melanoma models link heterogeneity with plasticity and response to immune checkpoint blockade
Presented by: Glenn Merlino
9:10am - 9:25am
Single cell profiling of tumor biopsies reveals molecular heterogeneity of response
Presented by: Esther Lim
9:25am - 9:40am
Regulation of anti-melanoma immune responses by the lncRNA LISR
Presented by: Eleonora Leucci
9:40am - 10:00am
Melanoma persistent cells from the Petri dish to the patients
Presented by: Caroline Robert
10:00am -10:06am
Flash Talks
Cytosolic EZH2-IMPDH2 complex regulates melanoma progression via GTP
Presented by: Meri Rogava
Phenotypic Melanoma Heterogeneity is Regulated through Cell-Matrix Interaction-Dependent Changes in Tumor Microarchitecture
Presented by: Nik Haass
10:05am - 10:30am
Refreshment Break
Cromdale Hall & Strathblane Hall
10:30am - 12:35pm
PLENARY SESSION 5 - Difficult Clinical Scenarios - Session Chair - Amaya Viros
Pentland Hall
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10:30am - 10:50am
Difficult clinical scenarios in the systemic management of melanoma
Presented by: Alex Menzies
10:50am - 11:05am
Dissecting brain metastasis response to immunotherapy in new immunocompetent mouse models
Presented by: Eva Perez-Guijarro
11:05am - 11:20am
Phase 2 Trial of Nivolumab/relatlimab in Metastatic Uveal Melanoma
Presented by: Jose Lutzky
11:20am - 11:40am
Invited Faculty Patricia Possik
11:40am - 11:55am
Phase 1 study of fianlimab (FIAN), a human lymphocyte activation gene-3 (LAG-3) monoclonal antibody, plus cemiplimab (CEMI) in advanced melanoma (mel)
Presented by: John Crown
11:55am - 12:15pm
Omission of Adjuvant Radiotherapy Does Not Increase the Risk of Lymph-Node Basin Relapse for Patients with High Risk Resected Stage III Melanoma in the Modern Treatment Era
Presented by: Nathan Kuehne
12:15pm - 12:35pm
Invited Faculty Michael Davies
12:35pm - 2:00pm
Lunch - Exhibit and Poster Viewing
Cromdale Hall & Strathblane Hall
2:00pm - 3:55pm
PLENARY SESSION 6 - Adjuvant and Neoadjuvant Therapies - Session Chair - Thomas Tueting
Pentland Suite
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2:00pm - 2:10pm
Introduction: where are we up to with adjuvant & neoadjuvant therapies?
Presented by: Georgina Long
2:10pm - 2:25pm
LATE BREAKING ABSTRACT: Adjuvant therapy with nivolumab versus placebo in patients with stage IIB/C melanoma (CheckMate 76K)
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Presented by: Georgina Long
2:25pm - 2:40pm
LATE BREAKING ABSTRACT: Adjuvant pembrolizumab (pembro) in stage II melanoma: outcomes in histopathologic subgroups in the phase 3 KEYNOTE-716 study
Presented by: Dirk Schadendorf
2:40pm - 2:55pm
Outcomes in patients (pts) with resected stage IIIA melanoma treated with adjuvant nivolumab (NIVO) or monitored with observation (OBS): a real-world study
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Presented by: Anna Pavlick
2:55pm - 3:10pm
Real-world outcomes of patients (pts) with resected stage IIIA melanoma treated with adjuvant nivolumab (NIVO) or monitored with observation (OBS)
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Presented by: Justin Moser
3:10pm - 3:25pm
Neoadjuvant ipilimumab and nivolumab in locally advanced or oligometastatic melanoma: clinical update with molecular and immunological biomarker’s analysis of the CA209-8HF study
Presented by: Pier Ferrucci Francesco
3:25pm - 3:45pm
Personalization of neoadjuvant immunotherapy in melanoma – the next steps to do
Presented by: Christian Blank
3:45pm - 4:00pm
Discussions
4:00pm - 4:30pm
Refreshment Break
Cromdale Hall & Strathblane Hall
4:30pm - 5:30pm
Keynote Presentation: Targets in DNA Damage Repair
Presented by: Roger Lo
Pentland Suite