VIRTUAL SESSIONS ARE NOT LIVE STREAMED. THEY WILL BE RECORDED AND PUBLISHED LATER FOR VIEWING.
Friday, October 11th
6:45am - 7:45am
CME Breakfast Symposium:
Melanoma Insights: Focus on High-Risk Early-Stage to Advanced Disease Management
Supported by Merck & Co. Inc.
7:00am - 5:00pm
Registration Open
8:00am-10:20am
Plenary Session 1
Developmental Immunotherapy (Cellular Immunotherapy, Vaccines, & New Checkpoints)
Chair: Allison Betof Warner
8:00am - 8:20am
Martin Wermke
ACTengine IMA203 TCR-T targeting PRAME in PD1 refractory metastatic melanoma – Clinical Update.
TIL therapy in metastatic melanoma in the era of modern immunotherapy; real-world experience.
8:20am - 8:35am
Jacob Schachter
8:35am - 8:50am
Evalstotug (BA3071): a potent conditionally active biologic (CAB) anti-CTLA-4 antibody designed to enable high exposures, extended dosing, and reduced immune-mediated toxicity
Bill Boyle
8:50am - 9:10am
Understanding the impact of prior treatment on TIL therapy: from bedside back to bench
Stephanie Goff
9:10am - 9:30am
Engineering a potent T cell response against melanoma
Christina Puig-Saus
9:30am - 9:45am
Efficacy and safety of RP1 combined with nivolumab in patients with anti–PD-1–failed melanoma from the IGNYTE clinical trial
Gino In
9:45am - 10:00am
KEYMAKER-U02 Substudy 02D: Lenvatinib (Len) + Coformulated Quavonlimab And Pembrolizumab (Qmab/Pembro) or Len + Pembro For Melanoma Brain Metastasis
Paolo Ascierto
10:00am - 10:20am
A Pilot Trial of Lifileucel for Melanoma Brain Metastases: Feasibility and Safety
Allison Betof Warner
10:20am - 10:40am
Refreshment Break
10:40am - 12:40pm
Plenary Session 2
Immune Microenvironment & Immunotherapy Resistance
Chair: Roberta Zappasodi
10:40am - 11:00am
Spatial location of gene expression signatures associated with resistance to immunotherapies
James Wilmott
11:00am - 11:15am
Regulatory T cells inhibit CD8+ TRM-like cells during the early stages of tumor immune escape
Jason Williams
11:15am - 11:35am
Translational insights from SWOG S1616: Stratification of patients with melanoma resistant to anti-PD-1
Katie Campbell
11:35am - 11:50am
Pharmacologic Modulation of Pituitary-Derived Prolactin Impacts Efficacy of Immune Checkpoint Inhibitor Therapy of Melanoma in a Preclinical Model
Mark Gregory
11:50am - 12:05pm
An HOXD13-CD73 gene regulatory axis promoting melanoma immune evasion
Pietro Berico
12:05pm - 12:25pm
Nociceptor neurons control anti-melanoma immunity
Tuany Eichwald
12:25pm - 12:40pm
Combining FAK Inhibition with the RAF/MEK Clamp Avutometinib Overcomes Resistance to BRAF/MEK Inhibitors and Immune Checkpoint Blockade in BRAFV600E Mutant Cutaneous Melanoma
Simone Lubrano
12:40pm - 2:00pm
Lunch- Exhibit and Poster Viewing
2:00pm - 3:55pm
Plenary Session 3
Non-Cutaneous Melanomas
Chair: Carla Daniela Robles-Espinosa
2:00pm - 2:20pm
Exploring the genetic landscape of Acral Melanoma from Latin American patients
Patricia Possik
2:20pm - 2:35pm
CK2 activation as a therapeutic target in acral melanoma
Ronaldo Perez-Lorenzo
2:35pm - 2:50pm
Tissue-Specific Inflammation Induces Cell State Plasticity with Oncogenic Addiction in Mucosal Melanoma
Hanlin Zeng
2:50pm - 3:05pm
Novel Mouse Models for Uveal Melanoma
Xiaonan Xu
3:05pm - 3:20pm
GDF15 reprograms the microenvironment to drive the development of uveal melanoma liver metastases
Sathya Neelature Sriramareddy
3:20pm - 3:35pm
Modeling Primary GNAQ-Driven Uveal Melanoma in Adult Zebrafish
Speaker TBD
3:35pm - 3:55pm
Mechanisms of dormancy and metastatic growth in uveal melanoma
Julius Yevdash
3:55pm - 4:15pm
Refreshment Break
4:15pm - 6:00pm
Concurrent Session 4A
Melanoma Metastasis
Chair: Inna Smalley
4:15pm - 4:35pm
Interferon-γ instructs the anti-tumor response in metastatic leptomeninges
Jan Remsik
4:35pm - 4:50pm
The role of intra-tumoral bacterial signal and distant microbiota in brain metastasis
Golnaz Morad
4:50pm - 5:05pm
Dissecting the Role of the Immune Microenvironment in Melanoma Bone Metastasis
Marija Simic
5:05pm - 5:20pm
Intratumor heterogeneity unravels organ-induced cellular programs favoring melanoma metastasis.
Panagiotis Karras
5:20pm - 5:35pm
Therapeutic strategies to induce dormancy of melanoma disseminated cancer cells
Maria Sosa
5:35pm - 5:55pm
Dissecting the biomechanical role(s) of the plantar skin microenvironment in driving acral melanoma metastases
Vito Rebecca
4:15pm - 6:00pm
Concurrent Session 4B
Epidemiology, Prevention, & Early Detection
Chair: Sancy Leachman
4:15pm - 4:20pm
Welcome and Introduction
Sancy Leachman
4:20pm - 4:40pm
Computer vision based approaches for melanoma early detection: early lessons about algorithm bias and usefulness
Albert Chiou
4:40pm - 4:55pm
Effect of chemokine (CK) and CK-receptor (CKR) gene variants on risk for developing multiple primary melanoma
Irene Orlow
4:55pm - 5:10pm
Time trends in the incidence of multiple primary melanomas in Australia
Anne Cust
5:10pm - 5:25pm
Sun-Protective Behaviors Among Skin Cancer Survivors: A National Health Interview Study
Hannah Verma
5:25pm - 5:40pm
Discovery and validation of an ancillary genomic test of malignancy for primary melanocytic tumors
Ismael Vergara Correa
5:40pm - 6:00pm
Saturation genome editing of melanoma predisposition genes
David Adams
6:00pm - 7:30pm
Poster Viewing Reception